IS YOUR BIOPROCESS IN CONTROL?
Dissolved carbon dioxide (DCO₂) is a critical process parameter (CPP) in biopharma production processes according to PAT guidelines. By influencing other parameters such as extracellular and intracellular pH, it has an effect on different metabolic pathways which are involved in cell growth or in product formation and quality.
BIOREACTOR SIZE IMPACTS DISSOLVED CO₂
Large and small bioreactors have Mass Transfer Coefficients (KLa) that change the dissolution and stripping characteristics from reactor to reactor. As a result the same control strategy will result in different CO₂ accumulation across R&D, PD, and Production scale reactors. Only real-time control of dissolved CO₂ to an optimized profile will result in comparable mass transfer independent of scale.
AUTOMATED CONTROL OF DISSOLVED CO₂ ENABLES:
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Increased titer: Increased product titer.
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Reproductivity: Better batch-to-batch reproductivity
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Consistency: More Consistency from R&D to Production Scale Reactors
Dissolved Carbon Dioxide
溶解二氧化碳探頭
CO2NTROL
Real-Time. Solid State. Made for Bioproduction.
Hamilton's CO₂NTROL is a solid-state sensor that directly measures DCO₂ and provides maintenance free, real-time, and in-line control of this important critical process parameter. Get automated control that enables increased titer, better batch-to-batch reproducibility, and more consistency from R&D to production-scale bioreactors.
Solid-state sensor
(no electrolyte)
Biopharma, Fermentation, Cell Cultures